Coming soon
Nanotoxicology
This course will enable the students :
- To engage students in significance of nanoparticles in human body.
- To develop basic skills and tools of experimental physics and data analysis
- To understand the role of direct observation in Physics and to distinguish between inferences based on theory and outcome of experiments.
Course outcomes (COs):
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Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Course Code |
Course Title |
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DNST 1001 C
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Nanotoxicology (Theory)
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The students will be able to:
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Approach in teaching: Interactive Lectures, Discussion, Tutorials, , Demonstration, Problem Solving in tutorials
Learning activities for the students: Self learning assignments, Effective questions, Seminar presentation, Solving numerical. Additional learning through online videos.
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Class test, Semester end examinations, Quiz, Solving problems, Assignments, Presentations . |
Mechanism of toxicity, doses, epidemiological evidences, entry routes, detoxification/and movement of nanoparticles in human body: lungs, intestinal tract, skin, CNS. Attributes contributing to nanomaterials toxicity.
Nanoparticles interaction with the biological membrane, uptake and toxicity at cellular level of different nanoparticles. Mechanisms of nanomaterial toxicity: oxidative stress, genotoxicity, hemolytic toxicity, mutagenicity and immunotoxicity.
Dose-Response Relationship, Spectrum of undesired effects: Allergic and Idiosyncratic reactions, Immidiate vs. Delayed toxicity. Biotransformation of Toxicants, Disposition of toxicants: ADME response
Assessment of nanomaterial toxicity: In vitro toxicity assessment-cell viability, lactate dehydrogenase release, reactive oxygen species generation, change in mitochondrial membrane potential and nuclear fragmentation.
In vivo toxicity assessment: inflammatory response, acute / subchronic/ chronic toxicity studies, LD50 determination, histopathological studies of Brain, Liver, Kidney and Behavioral Toxicity.
1.Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology, Saura C Sahu, Daniel A Casciano, Wiley Publishing, 2014
2.Nanotoxicology - Interactions of Nanomaterials with Biological Systems, Yuliang Zhao and Hari Singh Nalwa, American Scientific Publishers, 2007.
3.Biointeractions of Nanomaterials, Vijaykumar B. Sutariya, Yashwant Pathak, CRC Press, First Edition,2014
4.New Technologies for Toxicity Testing, Michael Balls, Robert D. Combes, Nirmala Bhogal. , Springer Science + Business Media,2012
5. Casarett and Daull’s Toxicology: The basic science of poisons. By: Curtis D. Klaassen 8th Edit., McGraw-Hill (Medical Publishing Div.) New York.
6. A Textbook of Modern Toxicology by Hodgson, E. (2010) A John Wiley & Sons. Inc.
