This course will enable the students to –
1. understand the concept of nanomedicines and their applications in drug delivery and nanodiagnostics.
Course outcomes (COs):
Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
|
Course Code |
Course Title |
|||
DNST 1001(A) |
Nanopharmaceuticals (Theory) |
On completion of this course, the students will be able to;
|
Approach in teaching: Interactive Lectures, Discussion, Tutorials, Demonstration, problem solving in tutorials
Learning activities for the students: Self-learning assignments, Effective questions, Seminar presentation, solving numerical. Additional learning through online videos. |
Class test, Semester end examinations, Quiz, Solving problems, Assignments, Presentations |
Nanobiotechnology for Drug Discovery- Use of Gold Nanoparticles, Quantum Dots and Nanolasers for Drug Discovery, Cells Targeting byNanoparticles,Nanoscale Devices for Drug Discovery, Drug Design at Cellular Level using Nanotechnology, Nanobiotechnology-Based Drug Development- DendrimersasDrugs, Fullerenes as Drug Candidates –Nanobodies, Nanobiotechnology in Drug Delivery, NanoscaleDelivery of Therapeutics, Nanosuspension Formulations, Viruses as Nanomaterials forDrug Delivery, NanoparticleBased Drug Delivery, Trojan Nanoparticles, Self-AssemblingNanoparticles for Intracellular Drug Delivery, Nanoparticle Combinations for Drug Delivery,Liposomes -Liposome–Nanoparticle Hybrids-Nanospheres, Nanotubes, Nanocochleates, Nanomolecular Valves for Controlled Drug Release, Nanomotors forDrugDelivery.
Introduction, Development of nanomedicines, Nano Shells, Nano pores, Tectodendrimers, Nanoparticle drug system for oral administration, nasal administration, ocular administration, Nanotechnology in diagnostic application.
Preformulation Studies: on various dosage forms such as tablets, capsules, suspension, creams, emulsion,injectables, ophthalmic and aerosols etc. Biomedical nanoparticles: Liposome’s – Dendrimers, Different types of drug loading, Drug release, Biodegradable polymers, Applications.Nanobiotechnologies for Single-Molecule Detection, Protease-Activated QuantumDot Probes, Nanotechnology forPoint-of-Care Diagnostics, Nanodiagnostics for the Battle Field, Nanodiagnostics for Integrating Diagnostics with Therapeutics.
Introduction and Rationale for Nanotechnologyin Cancer Therapy, Passive Targeting of SolidTumors: Pathophysiological Principles and Physicochemical Aspects of Delivery Systems, ActiveTargeting Strategies in Cancer with Nanotechnology Applications,Pharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery, MultifunctionalNanoparticles for Cancer Therapy, Neutron Capture Therapy of Cancer:Nanoparticlesand High Molecular Weight Boron Delivery Agents, Nano-OncologyNanoneurology, Nanocardiology, Nano-Orthopedics, Nano-Ophthalmology.
Introduction, Nano diagnostics-Rationale of Nanotechnology for Molecular Diagnostics, Nanoarrays for Molecular Diagnostics,NanoProTM System, Nanofluidic/Nanoarray Devices to Detect a Single Molecule of DNA-Self Assembling Protein Nanoarrays, Fullerene Photo detectors for Chemiluminescence, Detection on Micro fluidic Chips, Protein Microarray for Detection of Molecules with Nanoparticles Protein Nanobiochip, Nanoparticles for Molecular Diagnostics, Gold Nanoparticles, Quantum Dots for Molecular Diagnostics, Magnetic Nanoparticles-Use of Nanocrystals in Immunohisto chemistry, Imaging applications of Nanoparticles, Study of Chromosomes by Atomic ForceMicroscopy, Applications of Nanopore Technology for Molecular Diagnostics, DNA–Protein and DNA–Nanoparticle Conjugates.
DNA Nanomachines for Molecular Diagnostics, Nanobarcodes Technology, Nanobarcode Particle Technology for SNP Genotyping, QdotNanobarcode for Multiplexed Gene Expression Profiling, BiobarcodeAssay for Proteins, Single-Molecule Barcoding System for DNA Analysis, Nanoparticle Based Colorimetric DNA Detection Method, Cantilevers as Biosensors for Molecular Diagnostics, CarbonNanotube Biosensors, FRET-BasedDNANanosensors. Ion Channel Switch Biosensor Technology, Electronic Nanobiosensors, Electrochemical Nanobiosensors, Quartz Nanobalance Biosensors, Viral Nanosensors, PEBBLENanosensors, Microneedle-Mounted Biosensors, OpticalBiosensors, Nanowire (NW) Biosensors, Nanoscale ErasableBiodetectors.